Biotechnology and molecular biology of the α-glucosidase inhibitor acarbose
✍ Scribed by U.F. Wehmeier; W. Piepersberg
- Publisher
- Springer
- Year
- 2004
- Tongue
- English
- Weight
- 617 KB
- Volume
- 63
- Category
- Article
- ISSN
- 1432-0614
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Short-term studies with acarbose have demonstrated its ef®cacy in reducing postprandial blood glucose levels and glycated haemoglobin (HbA 1c ) levels. These effects would be expected to translate into improvements in long-term complications of diabetes, but such data are not yet available due to th
## Abstract This work deals with the design and synthesis of α‐glucosidase inhibitors. In order to perform this task, a molecular docking study was carried out with the __N__‐terminal catalytic subunit of human maltase glucoamylase, which evidenced a partially empty, hydrophobic part of the docking