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Biosynthetic studies of marine lipids 18. Biosynthesis of 3β-(hydroxymethyl)-A-nor-5α-cholest-15-ene in the marine sponge phakellia aruensis

✍ Scribed by Sohail Malik; Ivan L. Stoilov; Carl Djerassi

Publisher: Elsevier Science
Year: 1988
Tongue: French
Weight: 226 KB
Volume: 29
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)80422-0

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✦ Synopsis

Through appropriate labeling experiments, it was shown that the unusual sterol 3B-(hydroxymethyl)-A-nor-Sa-cholest-15-ene ( 1) is generated by ring contraction of dietary cholesterol followed by the introduction of the 15-16 double bond, rather than by ring contraction of 15-dehydrocholesterol (4).

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