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Biosynthetic incorporation of ethyl (RS) [2,3-13C2,3-14C]-4-(1-methyl-2-pyrrolidinyl)-3-oxobutanoate into cuscohygrine in Erythroxylum coca

✍ Scribed by Marcy L. Newquist; Timothy W. Abraham; Edward Leete


Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
388 KB
Volume
33
Category
Article
ISSN
0031-9422

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Synthesis of [carbonyl-14C]- and (methox
✍ Kazuharu Tamazawa; Hideki Arima 📂 Article 📅 1984 🏛 John Wiley and Sons 🌐 French ⚖ 485 KB

## Abstract A new potent neuroleptic agent YM‐09151‐2, N‐[(2RS, 3RS)‐1‐benzyl‐2‐methyl‐3‐pyrrolidinyl]‐5‐chloro‐2‐methoxy‐4‐ (methylamino) benzamide (**10c**), was labeled with carbon‐14 and deuterium for biochemical studies such as metabolism and 14 pharmacokinetics. The synthesis of [carbonyl‐^14