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Biosynthesis, processing and secretion of von Willebrand factor: biological implications

✍ Scribed by Thalia Romani de Wit; Jan A. van Mourik

Book ID
119754999
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
199 KB
Volume
14
Category
Article
ISSN
1521-6926

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Plasma von Willebrand factor (vWF) is a multimeric protein that mediates adhesion of platelets to sites of vascular injury, however only the very large vWF multimers are haemostatically competent. Plasma vWF derives predominantly from the vascular endothelium and is of a smaller average multimer siz