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Biosynthesis of the α chains of collagen

✍ Scribed by Karl A. Piez

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
606 KB
Volume
76
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

The α chains of collagen are synthesized like other proteins by the sequential addition of amino acids beginning at the amino‐terminal end and continuing for over 1000 amino acids. In addition to amino acid assembly, hydroxylation of certain prolyl and lysyl residues is required to complete the molecule. Approximately 4.8 minutes is necessary for the entire process. After extrusion from the cell, specific lysyl residues are oxidatively deaminated to the aldehyde allysine. An analogous conversion probably occurs with hydroxylysine. Cross‐linking results from the condensation of an aldehyde on one chain with an aldehyde or an ϵ‐amino group on another chain.

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