Biosynthesis of the polyether antibiotic narasin origins of the oxygen atoms and the mechanisms of ring formation

✍ Scribed by Z Spavold; J.A Robinson; D.L Turner

• Book ID: 104218862
• Publisher: Elsevier Science
• Year: 1986
• Tongue: French
• Weight: 258 KB
• Volume: 27
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)84781-4

✦ Synopsis

The biosynthesis of narasin in cultures of Streptomyces aureofaciens has been studied using [l-13C, l*OZ] labelled acetate and butyrate, and by incubation of cultures under an atmosphere of 180Z. The origins of the eleven oxygen atoms in narasin have thereby been established and this provides information regarding the mechanism of heterocyclic ring and bis-spiroketal formation.