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Biosynthesis of the Myxobacterial Antibiotic Corallopyronin A

✍ Scribed by Özlem Erol ; Till F. Schäberle ; Alexander Schmitz; Shwan Rachid; Cristian Gurgui; Mustafa El Omari; Friederike Lohr; Stefan Kehraus; Jörn Piel; Rolf Müller; Gabriele M. König

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
512 KB
Volume
11
Category
Article
ISSN
1439-4227

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✍ Jürgen Rohr; Carmen Méndez; Jose A. Salas 📂 Article 📅 1999 🏛 Elsevier Science 🌐 English ⚖ 332 KB

Biosynthetic studies on mithramycin (1, aureolic acid) using to a great extent modern genetic methods revealed several novel aspects of the biosynthesis of this class of antitumor agent. It could be proven that the aglycon moiety of the aureolic acids is constructed by a type II polyketide synthase