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Biosynthesis of the Heat-Shock Protein 90 Inhibitor Geldanamycin: New Insight into the Formation of the Benzoquinone Moiety

โœ Scribed by Dongho Lee; Kyeong Lee; Xing Fu Cai; Nguyen Tien Dat; Shanthaveerappa K. Boovanahalli; Mijeoung Lee; Jin Chul Shin; Woncheol Kim; Jae Kap Jeong; Jong Suk Lee; Choong-Hwan Lee; Jeong-Hyung Lee; Young-Soo Hong; Jung Joon Lee

Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
95 KB
Volume
7
Category
Article
ISSN
1439-4227

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Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells
โœ Yuo-Sheng Chang; Lee-Chen Lee; Fang-Chun Sun; Chih-Chung Chao; Hua-Wen Fu; Yiu-K ๐Ÿ“‚ Article ๐Ÿ“… 2005 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 269 KB ๐Ÿ‘ 2 views

Both geldanamycin (GA) and radicicol (RA) are HSP90 binding agents that possess antitumour activities. Although the in vitro data indicated that the inhibitory constant of RA is much bigger than that of GA, the in vivo data on drug efficacy might reveal different results. We have recently shown that