Treatment of equatorial cyclohexanols with Ph3P/DEAD/MsOH gives clean conversion to the axial mesylates. Subsequent reaction with NaN3 gives the equatorial azides in overall yields of 74-87%. Axial hydroxyl groups are not affected, allowing the regioselective conversion of methyl cholate into a 3ct-
β¦ LIBER β¦
Biosynthesis of the antibiotic thiostrepton. Methylation of tryptophan in the formation of the quinaldic acid moiety by transfer of the methionine methyl group with net retention of configuration
β Scribed by Zhou, Pei; O'Hagan, David; Mocek, Ursula; Zeng, Zhaopie; Yuen, Lai Duien; Frenzel, Thomas; Unkefer, Clifford J.; Beale, John M.; Floss, Heinz G.
- Book ID
- 127263111
- Publisher
- American Chemical Society
- Year
- 1989
- Tongue
- English
- Weight
- 357 KB
- Volume
- 111
- Category
- Article
- ISSN
- 0002-7863
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## Abstract Methyl ester of abscisic acid (ABA), a plant hormone, gives a dehydrated ion at __m__/__z__ 260 in electron ionization mass spectrometry (EIβMS). This dehydrated ion had been considered to be derived only from the elimination of the tertiary hydroxyl group at Cβ1β². We found that 34% of