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Biosynthesis of ravidomycin. Use of 13C-13C double quantum NMR to follow precursor incorporation

โœ Scribed by Guy T. Carter; Amedeo A. Fantini; John C. James; Donald B. Borders; Richard J. White

Book ID
104229945
Publisher
Elsevier Science
Year
1984
Tongue
French
Weight
233 KB
Volume
25
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

A biosynthetic scheme is proposed for the ravidcmycin aglycone. Incorporation of 13C-labeled precursors was followed by conventional and 2-dimensional NMR techniques. The yellow antitmr antibiotic ravidanycin 1, recently isolated frQn Streptanyces ravidusl, represents the newest member of the chrysomycin family of antibiotics. Possible routes for the biosynthesis of the aglycone portion of these antibiotics has been discussed by Weiss et a1.2 in conjunction with their work on the chryscmycins. Given the difficulty of

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