Biosynthesis of Nitric Oxide—Quantum Chemical Modelling of Nω-Hydroxy-l-arginine Formation

Synthesis of 15Nω-Hydroxy-L-arginine and

Synthesis of 15Nω-Hydroxy-L-arginine and ESR and 15N-NMR Studies for the Elucidation of the Molecular Mechanism of Enzymic Nitric Oxide Formation from L-Arginine

✍ Bernd Clement; Elke Schnörwangen; Thomas Kämpchen; Peter Mordvintcev; Alexander 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 509 KB

## Abstract __N__^ω^‐Hydroxy‐L‐arginine (2) was prepared by a multi‐stage synthesis; the key step was the addition of hydroxylamine to the protected cyanamide 8. The presence of __N__‐hydroxyguanidines was confirmed, above all, by ^15^N‐NMR investigations. ^15^__N__^ω^‐Hydroxy‐L‐arginine (2) was co