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Biosynthesis of galactosylsphingosine (Psychosine) in the twitcher mouse

โœ Scribed by Kunihiko Mitsuo; Takuro Kobayashi; Nobue shinnoh; Ikuo Goto

Publisher
Springer
Year
1989
Tongue
English
Weight
454 KB
Volume
14
Category
Article
ISSN
0364-3190

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โœ M. C. Skiba; T. A. Lyerla; J. T. Konola; Dr. S. Raghavan ๐Ÿ“‚ Article ๐Ÿ“… 1990 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 707 KB

The inherited deficiency of galactosylceramide pgalactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid co