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Biosynthesis of a Site-Specific DNA Cleaving Protein

✍ Scribed by Lee, Hyun Soo; Schultz, Peter G.

Book ID
121386175
Publisher
American Chemical Society
Year
2008
Tongue
English
Weight
396 KB
Volume
130
Category
Article
ISSN
0002-7863

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## Abstract We have prepared a series of a tailor‐made molecules that recognize and cleave DNA at apurinic sites __in vitro__. These molecules incorporate in their structure different units designed for specific function: an intercalator for DNA binding, an nucleic base for abasic site recognition