Biosynthesis and deficiency of lysosomal enzymes
โ Scribed by Tager, J.M.
- Book ID
- 123351004
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 310 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0968-0004
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๐ SIMILAR VOLUMES
Dictyostelium discoideum is a useful system to study the biosynthesis of lysosomal enzymes because of the relative ease with which it can be manipulated genetically and biochemically. Previous studies have revealed that lysosomal enzymes are synthesized in vegetatively growing amoebae as glycosylate
Despite the clear differences between the amino acid sequence and enzymatic specificity of aspartic and cysteine endopeptidases, the biosynthetic processing of lysosomal members of these two families is very similar. With in vitro translation and pulse-chase analysis in tissue culture cells, the bio