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BIOSSIM—A structured machine-independent biological simulation language

✍ Scribed by Gruia-Catalin Roman; David Garfinkel

Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
877 KB
Volume
11
Category
Article
ISSN
0010-4809

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✦ Synopsis

BIOSSIM is a revised and extended biochemical simulation language which has been rewritten in structured (machine-independent) FORTRAN to facilitate maintenance and modification. Its original capability to translate chemical reactions into differential equations and solve them has been greatly enhanced by provision to represent reactions at equilibrium and individual enzymes by primarily algebraic means, and by the capability to incorporate FORTRAN subroutines to modify or manipulate the solutions of the differential equations in order to more realistically represent physiological inputs to complex biological systems. Computational efficiency has been greatly enhanced by adaptation of the Gear stiff differential equation solver, which here runs effectively on computers of 32 bit wordlength, permitting minicomputer usage. Computational efficiency may be further improved by translating relatively small parts of the program into assembly language.

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