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Biophysical Properties of a Human Disease-Causing Mutation in CaV1.3 L-Type Calcium Channels

✍ Scribed by Lieb, Andreas; Baig, Shahid M.; Gebhart, Mathias; Dafinger, Claudia; Engel, Jutta; Sinnegger-Brauns, Martina J.; Mangoni, Matteo E.; Khan, Habib U.; Nürnberg, Peter; Bolz, Hanno J.; Koschak, Alexandra; Striessnig, Jörg

Book ID: 122209157
Publisher: Biophysical Society
Year: 2011
Tongue: English
Weight: 44 KB
Volume: 100
Category: Article
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2010.12.3301

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## Abstract Mammalian acrosome reaction (AR) requires successive activation of three different types of calcium channels (T‐type channels, Inositol‐3‐phosphate (InsP3) receptors, and TRPC2 channels). All the calcium signaling is under the control of the activation of the first‐one, a T‐type calcium