Biopharmaceutical Drug Design and Development Second Edition

✍ Scribed by Susanna Wu-Pong, Yon Rojanasakul

• Publisher: Humana Press
• Year: 2008
• Tongue: English
• Leaves: 374
• Edition: Second Edition
• Category: Library

✦ Synopsis

This book provides a comprehensive examination of the newest biopharmaceutical drugs. Among the drugs discussed are ones in the categories of monoclonal antibodies for in-vivo use, cytokines, growth factors, enzymes, immunomodulators, thrombolytics, and immonotherapies including vaccines. Additionally, the volume examines new and emerging technologies, and contains a review of the Human Genome Project.

✦ Table of Contents

Front......Page 1
Preface......Page 5
Contents......Page 7
Contributors......Page 9
1 Biotechnology: 2008 and Beyond......Page 11
2 The Human Genome Project and Drug Development......Page 25
3 The Use of Bioinformatics and Chemogenomics
in Drug Discovery......Page 40
4 DNA Microarrays in Drug Discovery and Development......Page 55
5 Microarray Technology Using Proteins, Cells, and TIssues......Page 75
6 Pharmacogenetic Issues in Biopharmaceutical Drug Development......Page 106
7 Development and Applications of Transgenics in Biotechnology
and Medicine......Page 128
8 Viral, Nonviral, and Physical Methods for Gene Delivery......Page 147
9 Stem Cell Technology and Drug Development......Page 180
10 Small Nucleic Acid-Based Drug: Successes and Pitfalls......Page 197
11 Therapeutic Strategies Targeting the Innate Antiviral Immune Response......Page 226
12 Pharmacogenetics in the Clinic......Page 255
13 Molecular Modeling: Considerations for the Design
of Pharmaceuticals and Biopharmaceuticals......Page 269
14 Macromolecular Drug Delivery......Page 294
15 Changes in Biologic Drug Approval at FDA......Page 325
16 Follow-On Protein Products: The Age of Biogenerics?......Page 344
Index......Page 366