𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Biopharmaceutical characteristics of a new propranolol/ hydrochlorothiazide tablet combination

✍ Scribed by M. Kraml; J. Dubuc; D. Dvornik; S. Patterson-Kreuscherv; H. Perdue; T. Y. Lee; J. Mullane

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
446 KB
Volume
3
Category
Article
ISSN
0142-2782

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Experiments have been carried out in dogs and man to determine the effect of hydrochlorothiazide (HCT) on the pharmacokinetics of propranlol and to evaluate the bioavailability of two dosage forms containing both propranolol and HCT (40/25 and 80/25 mg, respectively). In adult male beagles, 50 mg of HCT had no apparent effect on AUC, C~max~, T~max~, and T~1/2~ of propranolol administered concurrently. In man, INDERIDE® (40/25 mg) and INDERIDE® (80/25 mg) were shown to be similar in bioavailability to the reference formulations, i.e. the same amount of drugs administered as the separate tablets of INDERAL® plus HYDRODIURIL®.

📜 SIMILAR VOLUMES

Pharmacokinetic comparison of a combinat
Pharmacokinetic comparison of a combination tablet of enalapril and hydrochlorothiazide with enalapril and hydrochlorothiazide tablets administered together and separately
✍ L. G. Howes; E. L. Conway; P. A. Phillips; J. Broadbear; O. H. Drummer; W. J. Lo 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 401 KB 👁 1 views

Enalapril and hydrochlorothiazide (HCT) are established single agent treatments for mild hypertension and cardiac failure and are a potent combination in more severe or resistant cases. We have compared the pharmacokinetics of enalaprilat (the active metabolite of enalapril) and HCT in a four-way co

Absorption and disposition of a new low-
Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene
✍ Dr. R. L. Williams; E. T. Lin; W. Liang-Gee; C. D. Blume; L. Z. Benet 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 549 KB

Two studies are reported that assess the bioequivalence of a new half-strength drug combination containing 25 mg hydrochlorothiazide and 37.5 mg triamterene compared to a full-strength formulation containing 50 mg hydrochlorothiazide and 75 mg triamterene. The first study (I) compared the absorption