Biopharmaceutical challenges associated with drugs with low aqueous solubility—The potential impact of lipid-based formulations

Use of in vitro lipid digestion data to

Use of in vitro lipid digestion data to explain the in vivo performance of triglyceride-based oral lipid formulations of poorly water-soluble drugs: Studies with halofantrine

✍ Christopher J.H. Porter; Ann Marie Kaukonen; Agnes Taillardat-Bertschinger; Ben 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 196 KB 👁 1 views

The relative oral bioavailability (BA) of halofantrine base (Hf) was assessed in male beagle dogs after administration of a medium chain triglyceride (MCT), a long chain triglyceride (LCT), and a blended LCT/MCT lipid solution formulation of Hf (Study 1) and after administration of suspensions of Hf