Amphotericin B deoxycholate (AmBD) was introduced 45 years ago for the treatment of invasive mycoses, on the basis of open-label non comparative data. Throughout these years of use it proved to be a life-saving drug but also a toxic compound which under current approval criteria might not meet licen
Biopharmaceutical aspects of lipid formulations of amphotericin B
β Scribed by G. Storm; E. van Etten
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 943 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0934-9723
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A new aqueous nanoparticle system has been developed using complex coacervation employing the oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS), with zinc sulfate as a stabilizing agent. Amphotericin B (AmB) was loaded into the nanoparticles as a model drug. The nanoparticl
## Abstract ## BACKGROUND Invasive aspergillosis (IA) is associated with poor outcome in patients with hematologic malignancy treated with amphotericin B (AMB)βbased therapy. Itraconazole (ITC), a triazole with activity against __Aspergillus__, has been used in combination with AMB or lipid formul