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Bioorganometallic Chemistry – Synthesis and Antitumor Activity of Cobalt Carbonyl Complexes

✍ Scribed by Manfred Jung; David E. Kerr; Peter D. Senter

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
351 KB
Volume
330
Category
Article
ISSN
0365-6233

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✦ Synopsis

The interaction of organometallic compounds with biological systems, generally called bioorganometallic chemistry, is receiving increasing interest. We present the first part of our studies concerning the biological activity of organometallic compounds. Several alkyne-cobalt carbonyl complexes inhibited the growth of human melanoma and lung carcinoma cell lines. They are more active than uncomplexed dicobalt octacarbonyl, cobalt chloride, or the free ligand. A significant difference in potency towards the lung carcinoma cell line was observed among the cobalt complexes, indicating that the complexed ligand may influence cytotoxic activity. These results suggest that further exploratory work with such cobalt-alkyne complexes is warranted.

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