Bionanosphere Lithography via Hierarchical Peptide Self-Assembly of Aromatic Triphenylalanine
✍ Scribed by Tae Hee Han; Taedong Ok; Jangbae Kim; Dong Ok Shin; Hyotcherl Ihee; Hee-Seung Lee; Sang Ouk Kim
- Book ID
- 104593229
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 768 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1613-6810
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✦ Synopsis
Abstract
A nanolithographic approach based on hierarchical peptide self‐assembly is presented. An aromatic peptide of N‐(t‐Boc)‐terminated triphenylalanine is designed from a structural motif for the β‐amyloid associated with Alzheimer's disease. This peptide adopts a turnlike conformation with three phenyl rings oriented outward, which mediate intermolecular π–π stacking interactions and eventually facilitate highly crystalline bionanosphere assembly with both thermal and chemical stability. The self‐assembled bionanospheres spontaneously pack into a hexagonal monolayer at the evaporating solvent edge, constituting evaporation‐induced hierarchical self‐assembly. Metal nanoparticle arrays or embossed Si nanoposts could be successfully created from the hexagonal bionanosphere array masks in conjunction with a conventional metal‐evaporation or etching process. Our approach represents a bionanofabrication concept that biomolecular self‐assembly is hierarchically directed to establish a straightforward nanolithography compatible with conventional device‐fabrication processes.