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Biomonitoring of urine mutagenicity with the Ames test: improvement of the extraction/concentration method

✍ Scribed by Véronique Andre; Pierre Lebailly; Edwige Deslandes; Michel Henry-Amar; Pascal Gauduchon


Book ID
117766999
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
206 KB
Volume
520
Category
Article
ISSN
1383-5718

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The mutagenicity of tetrachloroethene (tetra) and its S conjugate, S-(1,2,2-trichlorovinyl)glutathione (TCVG) was investigated using a modified Ames preincubation assay. TCVG was a potent mutagen in presence of rat kidney particulate fractions containing high concentrations of y-glutamyl transpeptid