✦ LIBER ✦

Biomimicking Polysaccharide Nanofibers Promote Vascular Phenotypes: A Potential Application for Vascular Tissue Engineering

✍ Scribed by Liya Shi; Rachida Aid; Catherine Le Visage; Sing Yian Chew

Book ID: 102936143
Publisher: John Wiley and Sons
Year: 2011
Tongue: English
Weight: 745 KB
Volume: 12
Category: Article
ISSN: 1616-5187
DOI: 10.1002/mabi.201100336

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The potential of electrospun pullulan/dextran (P/D) nanofibers (average diameter = 323 nm) for vascular tissue engineering applications is explored. The mechanical properties of the nanofibers are of the same order of magnitude as that of human arteries (Young's modulus ≈0.88 MPa; tensile strength ≈0.35 MPa). It is demonstrated that the nanofiber topography enables cell adhesion and that the endothelial phenotype is maintained on the nanofibers. Moreover, P/D nanofibers support a stable confluent monolayer of endothelial cells over 14 d. SMCs seeded on nanofibers display similar levels of alpha smooth muscle actin and a lower proliferation rate than cells on 2D cultures. The observations suggest that nanofibers promote a shift to a quiescent contractile phenotype in SMCs.magnified image

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