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Biomimetic Total Synthesis of Litseaverticillols A, C, D, F, and G: Singlet-Oxygen-Initiated Cascades

✍ Scribed by Georgios Vassilikogiannakis; Manolis Stratakis

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
156 KB
Volume
115
Category
Article
ISSN
0044-8249

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✦ Synopsis

Scheme 1) are a recently isolated novel class of bioactive natural products. They were identified as the result of bioassay-guided fractionation of chloroform extracts from the leaves and twigs of a perennial shrub, Litsea verticillata Hance, found in Cuc Phuong National Park, Vietnam. [1] The eight new sesquiterpenes (1-8) were fully characterized because of their potent anti-HIV activity. More advanced biological studies revealed that compounds 1-8 inhibit HIV-1 replication in HOG.R5 cells (a reporter cell line) [2] with IC 50 values (the concentration required for 50 % inhibition) ranging from 2 to 15 mg mL Γ€1 (8-Scheme 1. Structures of litseaverticillols A-H. Scheme 2. Retrosynthetic analysis and strategy.

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