Biomimetic Oxidation of 2-Methylimidazole Derivative with a Chemical Model System for Cytochrome P-450.

Intratumoral activation of cyclophospham

Intratumoral activation of cyclophosphamide by retroviral transfer of the cytochrome P450 2B1 in a pancreatic tumor model. Combination with the HSVtk/GCV system

✍ Meritxell Carrió; Joana Visa; Anna Cascante; Xavier Estivill; Cristina Fillat 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 198 KB

## Abstract ## Background Pancreatic cancer is one of the most aggressive human tumors and the development of new therapeutic approaches is particularly urgent since current therapies are not effective. The use of pro‐drug‐activating genes is a possible approach for cancer gene therapy. ## Method