Biomedical Applications of Peptide-, Glyco- and Glycopeptide Dendrimers, and Analogous Dendrimeric Structures

✍ Scribed by Jaroslav Sebestik, Milan Reinis, Jan Jezek (auth.)

• Publisher: Springer-Verlag Wien
• Year: 2012
• Tongue: English
• Leaves: 244
• Edition: 1
• Category: Library

✦ Synopsis

Dendrimers are repeatedly branched and roughly spherical large molecules. They can be used in various medical applications, such as anticancer polymeric nanomedicines and nanocarriers, gene carriers and vectors in gene delivery, contrast agents for molecular imaging and vaccines against infectious diseases and cancer. The highly branched, multivalent nature and molecular architecture of dendrimers make them ideal tools for a variety of tissue engineering applications. This book describes different categories of dendrimers, their biomedical and physico-chemical applications as well as convergent and divergent syntheses, click chemistry and ligation strategies. It is a rich source of information for researchers in biochemistry and pharmacology working on drug development as well as for organic chemists who are engaged in synthesis of dendrimers.

✦ Table of Contents

Front Matter....Pages i-xvii
Introduction....Pages 1-5
Front Matter....Pages 7-7
Definition of Terms and Nomenclature....Pages 9-22
Sugar Code (Glycocode)....Pages 23-27
Classes of Peptide-, Glyco-, and Glycopeptide Dendrimers....Pages 29-44
The Dendritic State and Dendritic Effects....Pages 45-54
Synthesis of Dendrimers: Convergent and Divergent Approaches....Pages 55-81
Purification and Characterization of Dendrimers....Pages 83-92
Dendrimeric Libraries....Pages 93-98
Dendrimers in Catalysis....Pages 99-102
Front Matter....Pages 103-103
Dendrimers and Solubility....Pages 105-109
Biocompatibility and Toxicity of Dendrimers....Pages 111-114
Dendrimers in Nanoscience and Nanotechnology....Pages 115-129
Dendrimers in Drug Delivery....Pages 131-140
Dendrimers in Gene Delivery....Pages 141-147
Dendrimers and Bacteria....Pages 149-159
Dendrimers and Viruses....Pages 161-170
Dendrimers and Parasites....Pages 171-173
Cancer....Pages 175-182
Diagnostics, Lectin Detection and Cell–Cell Interactions....Pages 183-190
Dendrimers as Biosensors and Imaging Tools....Pages 191-195
Front Matter....Pages 103-103
Dendrimers Regulating Intracellular Signaling Pathways....Pages 197-198
Vaccines and Immunomodulation....Pages 199-207
Dendrimers in Neurodegenerative Diseases....Pages 209-221
Conclusions and Perspectives....Pages 223-224
Back Matter....Pages 225-238

✦ Subjects

Molecular Medicine; Biomedicine general; Pharmaceutical Sciences/Technology