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Biomedical applications of degradable polyphosphazenes

✍ Scribed by Etienne Schacht; Joke Vandorpe; Stéphane Dejardin; Yahia Lemmouchi; Leonard Seymour

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
538 KB
Volume
52
Category
Article
ISSN
0006-3592

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✦ Synopsis

This article describes the synthesis of biodegradable polyphosphazenes. The rate of degradation can be varied in a controllable manner by the introduction of hydrolysis-sensitive amino acid ester side groups or by blending of polymers. Biodegradable polyphosphazenes can be used for the preparation of drug-containing implants and this is illustrated for devices containing the cytostatic agent mitomycin C. This article reviews data about the degradation characteristics of poly[(amino acid ester)phosphazenel derivatives that have been discussed previously. Some new data about MMC-containing poly-[(organo)phosphazenel devices are discussed as well. 0

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