Biomechanical properties of human intervertebral discs subjected to axial dynamic compression—Influence of age and degeneration

Alterations of ADAMTSs and TIMP-3 in hum

Alterations of ADAMTSs and TIMP-3 in human nucleus pulposus cells subjected to compressive load: Implications in the pathogenesis of human intervertebral disc degeneration

✍ Ming Huang; Hai-Qiang Wang; Qiang Zhang; Xiao-Dong Yan; Meng Hao; Zhuo-Jing Luo 📂 Article 📅 2011 🏛 Elsevier Science 🌐 English ⚖ 266 KB

## Abstract Intervertebral disc degeneration (IDD) pertains to the loss of extracellular matrix (ECM), particularly the early loss of aggrecan, the turnover of which is regulated by ADAMTSs. Amongst the etiological factors of IDD, mechanical stress plays an important role in the physiological and p