Biomechanical analysis of a synthetic, biodegradable impaction graft substitute

✍ Scribed by Cameron Lutton; David Wheatley; Lance Wilson; Wietske Van der Velden; Ross Crawford; Ben Goss

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 331 KB
• Volume: 95A
• Category: Article
• ISSN: 1549-3296
• DOI: 10.1002/jbm.a.32843

✦ Synopsis

Abstract

Impaction bone grafting in revision arthroplasty is a common and successful procedure to restore primary bone stock. Reducing the amount of bone needed to fill large grafts has been a driving force for the use of synthetic materials that can act as extenders or substitutes. To this end, we evaluated the mechanical properties of a new class of biodegradable polymer beads with and without donor bone to determine its suitability for use in impaction grafting. Biodegradable methacrylated anhydride beads were synthesized using thermal polymerization techniques. The mechanical properties of the beads were then tested in an impaction grafting test chamber and compared with morsellised porcine allograft. The beads, porcine allograft and a 50/50 combination all had similar mechanical properties, both in compression and relaxation. Pure polymer beads compacted significantly less than pure allograft and retained macroporosity after impaction. Our results suggest that the biodegradable beads have sufficient mechanical properties to be considered as an impaction grafting substitute or extender. Their ability to fill space whilst retaining macroporosity may be advantageous for tissue ingrowth and remodeling. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.