## Abstract Limited osseointegration of current orthopedic biomaterials contributes to the failure of implants such as arthroplasties, bone screws, and bone grafts, which present a large socioeconomic cost within the United States. These implant failures underscore the need for biomimetic approache
Biomaterials for skin and bone replacement and repair in plastic surgery
β Scribed by Stephen M. Warren; Kenton D. Fong; Randall P. Nacamuli; HanJoon M. Song; Tony D. Fang; Michael T. Longaker
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 941 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1071-0949
No coin nor oath required. For personal study only.
β¦ Synopsis
Fabricating new tissues requires an interdisciplinary approach that combines developmental, cellular, and molecular biology with clinical medicine, biochemistry, immunology, engineering, and the material sciences. While many researchers are attempting to replicate endogenous structures to create new tissues, numerous barriers must be overcome to create complex, vascularized, patient-specific tissue constructs for replacement and repair. Although multi-step, multi-component tissue fabrication requires an amalgamation of ideas, for clarity we will limit this review to recent developments in the application of natural and synthetic bioabsorbable scaffolds. Herein, we highlight biomaterials potentially useful to plastic and reconstructive surgeons that are currently being used or developed for the replacement and repair of skin and bone.
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