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Biomarkers of the Insulin-Like Growth Factor Pathway Predict Progression and Outcome in Lung Cancer

✍ Scribed by David D. Shersher; Michael S. Vercillo; Cristina Fhied; Sanjib Basu; Omid Rouhi; Brett Mahon; John S. Coon; William H. Warren; L. Penfield Faber; Edward Hong; Philip Bonomi; Michael J. Liptay; Jeffrey A. Borgia


Book ID
113473522
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
623 KB
Volume
92
Category
Article
ISSN
0003-4975

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## Abstract Insulin‐like growth factor‐I receptor (IGF‐IR) is often overexpressed in malignant tumors, and is involved in the establishment and maintenance of malignant phenotypes. Tyrosine kinase receptor endocytosis is commonly triggered by ligand binding and occurs via clathrin‐coated vescicles