Biomarkers in Inflammatory Bowel Diseases

✍ Scribed by Nik Sheng Ding, Peter De Cruz

• Publisher: Springer International Publishing
• Year: 2019
• Tongue: English
• Leaves: 355
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book provides a comprehensive and complete overview of biomarkers in clinical practice for inflammatory bowel disease (IBD) bringing together the literature in a clear and concise manner. The book bridges the gap between growing knowledge at the bench and current and future applications of biomarkers in clinical practice.

The central structure of the book focuses on prognostic and predictive biomarkers in IBD with an emphasis on the fields of research and scientific techniques (genomics, proteomics and metabonomics) that have led to biomarker discovery and places these biomarkers within a clinical context to help understand their utility in clinical practice.

This book will be of use to clinicians who have an interest in using biomarkers in clinical practice as well as clinician researchers and scientists involved in the biomarker research pipeline.

The author team comprises experts from around the world in order to bring together the literature in an effort to inform clinicians and researchers about the current state-of-the art in biomarker discovery. It is intended to assist future research efforts and indicate how biomarkers might be best applied to clinical practice both at present and in the future.

✦ Table of Contents

Front Matter ....Pages i-xvii
Introduction (James Rickard, Nik Sheng Ding, Peter De Cruz)....Pages 1-6
Front Matter ....Pages 7-7
Clinical Risk Factors: Lessons from Epidemiology (Zsuzsanna Kurti, Zsuzsanna Vegh, Lorant Gonczi, Peter L. Lakatos)....Pages 9-22
Disease Modification in Crohn’s Disease (Patrick B. Allen, Laurent Peyrin-Biroulet)....Pages 23-29
Personalized Medicine - Dream or Reality? (Elizabeth A. Spencer, Marla C. Dubinsky)....Pages 31-44
Clinical Trial Design to Facilitate Biomarker Discovery (Anne S. Strik, Toer W. Stevens, Geert R. D’Haens)....Pages 45-53
Front Matter ....Pages 55-55
Luminal Crohn’s Disease (Amanda M. Lynn, Edward V. Loftus Jr)....Pages 57-71
Fibrosis and Stricturing Disease in Crohn’s Disease (Satya V. Kurada, Florian Rieder)....Pages 73-87
Postoperative Crohn’s Disease (Kurvi Patwala, Peter De Cruz)....Pages 89-97
Perianal Crohn’s Disease (Wing Yan Mak, Siew Chien Ng)....Pages 99-118
Front Matter ....Pages 119-119
Biomarkers in Acute Severe Ulcerative Colitis (Matthew C. Choy, Dean Seah, Peter De Cruz)....Pages 121-130
Chronic Active Ulcerative Colitis (Rose Vaughan, Britt Christensen, David T. Rubin)....Pages 131-140
Refractory Proctitis (Ian Craig Lawrance)....Pages 141-153
UC Surveillance (Chang-Ho Ryan Choi, Ibrahim Al-Bakir)....Pages 155-167
The Role of Biomarkers in the Ileal Anal Pouch (Jonathan P. Segal, Ailsa L. Hart)....Pages 169-180
Front Matter ....Pages 181-181
Extra-intestinal Manifestations in Inflammatory Bowel Disease: Diagnosis and Management (Ramesh Paramsothy, Peter Irving)....Pages 183-189
Primary Sclerosing Cholangitis Overlapping with IBD (João Sabino, Joren tenHove, Joana Torres)....Pages 191-204
Pregnancy and IBD (Emma Flanagan, Sally Bell)....Pages 205-215
Nutrition in IBD (Zubin Grover, Peter Lewindon)....Pages 217-231
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Thiopurines (Ashish Srinivasan, Peter De Cruz, Daniel van Langenberg)....Pages 233-241
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Optimising Therapeutic Effectiveness of Biologics (Ashish Srinivasan, Nik Sheng Ding, Daniel van Langenberg, Peter De Cruz)....Pages 243-255
Drug Toxicity: Personalising IBD Therapeutics – The Use of Genetic Biomarkers to Reduce Drug Toxicity (Gareth Walker, Tariq Ahmad)....Pages 257-269
Biomarkers for Remote Monitoring (Petra Weimers, Dorit Vedel Ankersen, Pia Munkholm)....Pages 271-278
Front Matter ....Pages 279-279
Exposome and Diet (Jakob Seidelin, Johan Burisch)....Pages 281-291
The Microbiome in IBD (Agathe Peyrottes, Phillippe Seksik, Joël Doré, Philippe Marteau)....Pages 293-301
Metabolic Profiling in IBD (Maria Glymenaki, Jia V. Li, Julian R. Marchesi)....Pages 303-312
Innate and Adaptive Immunology (Nurulamin M. Noor, Tim Raine)....Pages 313-321
Genetic and Genomic Markers for Prognostication (Nurulamin M. Noor, Miles Parkes, James C. Lee)....Pages 323-331
Risk Alleles for Drug Targets: Genomic Markers of Drug Response (Ryan Ungaro, Judy Cho)....Pages 333-341
Front Matter ....Pages 343-343
Big Data Meets Real World! The Use of Clinical Informatics in Biomarker Research (Siddharth Singh)....Pages 345-352
Bringing It Altogether: A Systems Biology Approach to Biomarkers in Inflammatory Bowel Disease (Claudio Fiocchi)....Pages 353-358
Back Matter ....Pages 359-365

✦ Subjects

Medicine & Public Health; Gastroenterology; Microbial Genetics and Genomics; Proteomics