Biology, Risk Stratification, and Therapy of Pediatric Acute Leukemias: An Update
β Scribed by Pui, Ching Hon (author);Carroll, William L. (author);Meshinchi, Soheil (author);Arceci, Robert J. (author)
- Book ID
- 111972808
- Publisher
- American Society of Clinical Oncology
- Year
- 2011
- Tongue
- English
- Weight
- 206 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0732-183X
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## Abstract ## BACKGROUND Much progress has been made in understanding the biology of acute lymphoblastic leukemia (ALL). This has translated into the recognition of several subgroups of ALL and the institution of riskβadapted therapies. New therapies are emerging based on the definition of specif
for socio-economic factors and the improvement in outcomes in the recent era may reflect better characterization of leukemia and therapy assignment [4,5]. There remains a need for a large-scale assessment of pharmacogenetic polymorphism that might influence outcome of therapy, and such a study is un
## Abstract ## Background Acute lymphoblastic leukemia (ALL) represents the most common malignancy of childhood. Its incidence peaks in children just before school entry age; i.e., in 2β3 year olds. It is known to be more common in white children in the USA; the incidence is also higher in boys th