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Biology, Clinical Relevance, and Molecularly Targeted Therapy in Acute Leukemia with Flt3 Mutation

✍ Scribed by Hitoshi Kiyoi; Tomoki Naoe

Book ID: 111835587
Publisher: Carden Jennings Publishing
Year: 2006
Tongue: English
Weight: 364 KB
Volume: 83
Category: Article
ISSN: 0925-5710
DOI: 10.1532/ijh97.06071

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## Abstract ## BACKGROUND Recently, an internal tandem duplication of the __FLT3__ gene (__FLT3__/ITD) was found in approximately 20% of adult acute myeloid leukemia (AML) cases and associated with a poor outcome. However, there are few studies on __FLT3__/ITD in childhood AML, and the clinical si