✦ LIBER ✦

Biology and pathobiology of gap junctional channels in hepatocytes

✍ Scribed by Mathieu Vinken; Tom Henkens; Evelien De Rop; Joanna Fraczek; Tamara Vanhaecke; Vera Rogiers

Publisher: John Wiley and Sons
Year: 2007
Tongue: English
Weight: 271 KB
Volume: 47
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.22049

No coin nor oath required. For personal study only.

✦ Synopsis

Distribution and Formation. Gap junctional channels are composed of two connexons of adjacent cells, which in turn are built up by six connexin proteins. At present, more than 20 connexin species have been cloned from humans and rodents. They all share a similar structure of four membrane-spanning domains, two extracellular loops, one cytoplasmic loop, one cytosolic N-terminal tail, and one C-terminal region (Fig. 1). Connexins are named after their molecular weight (expressed

📜 SIMILAR VOLUMES

Gap junctions and growth control in live

Gap junctions and growth control in liver regeneration and in isolated rat hepatocytes

✍ K E Fladmark; B T Gjertsen; A Molven; G Mellgren; O K Vintermyr; S O Døskeland 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

A persisting enigma is why gap junctions become The hepatocytes in the mature normal liver are tightly more sparse during liver regeneration. 10-17 coupled through gap junctions, except during compen- The growth-control hypothesis proposed by Loewenstein satory hyperplasia (regeneration) after part

Evidence for hemi-gap junctional channel

Evidence for hemi-gap junctional channels in isolated horizontal cells of the skate retina

✍ Dr. R. P. Malchow; Dr. H. Qian; H. Ripps 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 780 KB

Prolonged depolarization of isolated, voltageclamped skate retinal horizontal cells produces an outward current that exhibits a late onset and develops slowly with time. This current, which we refer to as the Q-current, is associated with an increase in membrane conductance, and is present when othe

Impact of aquaporin-4 channels on K+ buf

Impact of aquaporin-4 channels on K+ buffering and gap junction coupling in the hippocampus

✍ Susan Strohschein; Kerstin Hüttmann; Siegrun Gabriel; Devin K. Binder; Uwe Heine 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 305 KB

is the main water channel in the brain and primarily localized to astrocytes where the channels are thought to contribute to water and K 1 homeostasis. The close apposition of AQP4 and inward rectifier K 1 channels (Kir4.1) led to the hypothesis of direct functional interactions between both channel

Suppressed gap junctional intercellular

Suppressed gap junctional intercellular communication in carcinogenesis of endometrium

✍ Tsuyoshi Saito; Makoto Nishimura; Ryuichi Kudo; Hiroshi Yamasaki 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 301 KB

To examine whether and at which stage of endometrial carcinogenesis decreased connexin expression occurs, we investigated changes in the expression of the gap junction proteins, connexin 26 (Cx26), Cx32 and Cx43, in human endometrial hyperplasia and cancer samples. Forty-eight endometrial tissue sam

Gap junctional communication and regulat

Gap junctional communication and regulation of the glycogenic response to insulin by cell density and glucocorticoids in cultured fetal rat hepatocytes

✍ Mashiat U. Siddiqui; Samia Benatmane; Jean-Luc Zachayus; Christiane Plas 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 266 KB 👁 1 views

Cell culture studies have revealed that metabolic functions of the adult hepatocyte are related to cell density. Development of the glycogenic response to insulin under glucocorticoid control was investigated in 15-and 18-dayold fetal rat hepatocytes plated at different cell densities. After culturi

Injury of skeletal muscle and specific c

Injury of skeletal muscle and specific cytokines induce the expression of gap junction channels in mouse dendritic cells

✍ Liliana A. Corvalán; Roberto Araya; María C. Brañes; Pablo J. Sáez; Alexis M. Ka 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 407 KB

## Abstract Dendritic cells (DCs) in culture express at least connexin43, a protein subunit of gap junctions, and form gap junction channels, which could be important for T‐cells activation. Here, we evaluated whether DCs express connexins in vivo and also to identify components of their microenvir