Biology and clinical use of GM-CSF in lung cancer
✍ Scribed by Peter Drings; Jürgen R. Fischer
- Book ID
- 110650739
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 625 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0341-2040
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The toxicity and efficacy of recombinant human granulocyte-macrophage colony-stimulating factor (rhuGM-CSF) is established in adults, but limited information is available on its use in children. The profound myelotoxicity induced by cisplatin (40 mg/m2 daily x 5) and etoposide (150 mg/m2 daily x 3)
Granulocyte-macrophage colony stimulating factor (GM-CSF) gene expression and protein production were investigated in colorectal cancer cell lines and surgical specimens. In 6 of 6 established tumor lines, expression of the GM-CSF gene was observed by reverse transcription polymerase chain reaction