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Biologically-significant scavenging of the myeloperoxidase-derived oxidant hypochlorous acid by some anti-inflammatory drugs

✍ Scribed by Mohammad Wasil; Barry Halliwell; Christopher P. Moorhouse; Duncan C.S. Hutchison; Harold Baum


Book ID
115779795
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
445 KB
Volume
36
Category
Article
ISSN
0006-2952

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Neutrophils use a bactericidal mechanism through the release of the enzyme myeloperoxidase which catalyzes the formation of the powerful oxidant hypochlorous acid (HOCl) from H2O2 and Cl-. HOCl can inactivate alpha 1-antiproteinase (alpha 1-AP) which causes increased proteolytic activity at sites of