Biologically active polymer: controlled-release formulations based on Hymexazol

✍ Scribed by Limin Tai; Dongxue Liu; Yongjia Shen; Naiguo Si

• Publisher: John Wiley and Sons
• Year: 2002
• Tongue: English
• Weight: 93 KB
• Volume: 51
• Category: Article
• ISSN: 0959-8103
• DOI: 10.1002/pi.1035

✦ Synopsis

Abstract

3‐(2‐Hydroxyethoxy)‐5‐methylisoxazole (2) was prepared by the reaction of 3‐hydroxy‐5‐methylisoxazole (1) with 2‐ethylene chlorohydrin. It reacted with methacryloyl chloride to afford 2‐[3‐(5‐methylisoxazolyl)oxy]ethyl methacrylate (4). The compounds 2 and 4 were confirmed structurally by IR, MASS and ^1^H NMR spectroscopy and MS. The fungicidal effects of 2 and 4 were investigated. Compound 4 was subjected to radical copolymerization with acrylamide and formed a copolymer 5. It would release the active agent 2 in a reasonable amount by a hydrolysis process. The release rates of the compound 2 were determined by high performance liquid chromatography (HPLC) under different pH conditions. The results indicate that the copolymer 5 is potentially useful for the development of the chemically controlled‐released formulations of Hymexazol.

© 2002 Society of Chemical Industry