Biological significance of the expression of HIV-related chemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines

Isolated human astrocytes are not suscep

Isolated human astrocytes are not susceptible to infection by M- and T-tropic HIV-1 strains despite functional expression of the chemokine receptors CCR5 and CXCR4

✍ Agnès Boutet; Hassan Salim; Yassine Taoufik; Pierre-Marie Lledo; Jean-Didier Vin 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 496 KB

## Abstract Within the brain, HIV‐1 targets the microglia and astrocytes. Previous studies have reported that viral entry into astrocytes is independent of CD4, in contrast to microglia. We aimed to determine whether chemokine receptors play a role in mediating CD4‐independent HIV‐1 entry into astr