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Biological significance of chromosomal imbalance aberrations in gastrointestinal stromal tumors

✍ Scribed by Yi Chen; Ching-Cherng Tzeng; Chiou-Ping Liou; Ming-Yu Chang; Chien-Feng Li; Ching-Nan Lin


Publisher
BioMed Central
Year
2004
Tongue
English
Weight
887 KB
Volume
11
Category
Article
ISSN
1021-7770

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## Abstract Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract. The tumors characteristically harbor __KIT__ or __PDGFRA__ mutations, and mutant tumors respond to imatinib mesylate (Glivecβ„’). Chromosomal imbalances resulting in altered gene dosa

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## Abstract Gastrointestinal stromal tumors (GISTs) are mesenchymal neoplasms characterized by frequent chromosome arm 14q losses. In this study, the 14q changes in a series of 39 histologically and immunohistochemically confirmed GISTs were analyzed in detail by metaphase and/or interphase fluores