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Biological properties of VEGF/VPF receptors

✍ Scribed by Bruce I. Terman; Maureen Dougher-Vermazen

Publisher
Springer
Year
1996
Tongue
English
Weight
317 KB
Volume
15
Category
Article
ISSN
0167-7659

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✦ Synopsis

Several experimental findings have emphasized the significant role played by Vascular Endothelial Growth Factor/Vascular Permeability Factor (VEGF/VPF) in tumor angiogenesis. For example, VEGF/VPF actions are predominantly restricted to endothelial cells [1], and the expression of VEGF/ VPF is enhanced in tumor cells that lack oxygen and glucose [2]. In addition, inhibiting the interaction of VEGF/VPF with endothelial cells slows the growth of several tumors in vivo [3,4]. The purpose of this review is to summarize what is known concerning one aspect of the biology of VEGF/VPF, the interaction of the growth factor with its cell surface receptors.

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