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Biological Production of Semisynthetic Opiates Using Genetically Engineered Bacteria

✍ Scribed by French, Christopher E. ;Hailes, Anne M. ;Rathbone, Deborah A. ;Long, Marianne T. ;Willey, David L. ;Bruce, Neil C.

Book ID
109905666
Publisher
Nature Publishing Group
Year
1995
Tongue
English
Weight
360 KB
Volume
13
Category
Article
ISSN
1087-0156

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## Abstract Penicillin G amidase (PGA) is a key enzyme for the industrial production of penicillin G derivatives used in therapeutics. __Escherichia coli__ ATCC 11105 is the more commonly used strain for PGA production. To improve enzyme yield, we constructed various recombinant __E. coli__ HB101 a