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Biological monitoring of occupational exposure to toluene diisocyanate

✍ Scribed by A. Maître; M. Berode; A. Perdrix; S. Romazini; H. Savolainen

Publisher
Springer-Verlag
Year
1993
Tongue
English
Weight
349 KB
Volume
65
Category
Article
ISSN
0340-0131

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✦ Synopsis

The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam production were studied Their exposure levels varied in 8-h time-averaged samples from 9 5 to 94 gtg/m 3 The urinary TDA concentrations varied from 6 5 to 31 7 lg/g creatinine and they were linearly related to the atmospheric TDI levels Approximately 20 % of TDI is metabolized to diamines but their specificity is remarkable to the extent that by analysis for the 2,4 and 2,6-diamino isomers an idea of the percutaneous absorption may be had.

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