Biological function in a non-native partially folded state of a protein
✍ Scribed by Bemporad, Francesco; Gsponer, Joerg; Hopearuoho, Harri I; Plakoutsi, Georgia; Stati, Gianmarco; Stefani, Massimo; Taddei, Niccolò; Vendruscolo, Michele; Chiti, Fabrizio
- Book ID
- 109849710
- Publisher
- Nature Publishing Group
- Year
- 2008
- Tongue
- English
- Weight
- 507 KB
- Volume
- 0
- Category
- Article
- ISSN
- 0261-4189
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📜 SIMILAR VOLUMES
## Background: We present a simple method to train a potential function for the protein folding problem which, even though trained using a small number of proteins, is able to place a significantly large number of native conformations near a local minimum. the training relies on generating decoys b
## Abstract In this study, free‐energy function (FEF) for discriminating the native fold of a protein from misfolded decoys was investigated. It is a physics‐based function using an all‐atom model, which comprises the hydration entropy (HE) and the total dehydration penalty (TDP). The HE is calcula