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Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor

โœ Scribed by Sangku Lee; Jae Nyoung Kim; Hyeong Kyu Lee; Kab Seog Yoon; Ki Deok Shin; Byoung-Mog Kwon; Dong Cho Han

Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
273 KB
Volume
21
Category
Article
ISSN
0960-894X

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โœฆ Synopsis

A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization.

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## Abstract Diarylisoxazole derivatives (VI), analogues of the strongly antimitotic compound KRIBB3, are synthesized and evaluated for their antiproliferative activity.