Biological drug duo delivers one-two tumor punch

There may be two tumor suppressor genes

There may be two tumor suppressor genes on chromosome arm Ip closely associated with biologically distinct subtypes of neuroblastoma

✍ Osamu Takeda; Chieko Homma; Nobuo Maseki; Masaharu Sakurai; Naotoshi Kanda; Manf 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 746 KB

## Abstract We studied loss of heterozygosity (LOH) on chromosome arm Ip in 108 neuroblastomas using 14 polymorphic DNA markers. One‐hundred and four tumors with one or more informative loci; 21 (20%) of the 104 tumors showed LOH on Ip, and were classified into three groups on the basis of intersti