𝔖 Bobbio Scriptorium
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Biological consequences of the complementary structure of DNA. (Abstract)

✍ Scribed by Watson, J. D.

Book ID
102309801
Publisher
Wiley (John Wiley & Sons)
Year
1955
Tongue
English
Weight
467 KB
Volume
45
Category
Article
ISSN
0095-9898

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✦ Synopsis

3 . I). WA'J'SOS Califoriim Ircatitrtte of ~t ' C h ? I O ~O g t J , Pasadena

Although the chemical formula of DSh has suggested that tlie basic structure is that of a very long, unbranched pol>-iincleoticle chain, recent X-ray diffraction evidence (TVilkins ef oZ., '53 ; Franklin and Gosling, '53 ; \Vatson anti Crick, '53a) reveals that the fundamental stcrc~ochcmical unit contains two lielically intertwined chains. Tlie cliains are joined togvthcr by hydrogen bonds bctwcen pairs of bases, a single 1)asc. in one chain being hydrogen bonded to it single base frorii thc. other. The bonding sclicme is highly specific; not only must one inember be a purine and the other a pyrimidine, but adenine must pair with thymine and guanine with cytosine.

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## Abstract The mechanical properties of DNA play a critical role in many biological functions. For example, DNA packing in viruses involves confining the viral genome in a volume (the viral capsid) with dimensions that are comparable to the DNA persistence length. Similarly, eukaryotic DNA is pack