✦ LIBER ✦

Biological clock mutants and parameter changes in mathematical models

✍ Scribed by Theodosios Pavlidis

Publisher: Springer
Year: 1975
Tongue: English
Weight: 537 KB
Volume: 37
Category: Article
ISSN: 1522-9602
DOI: 10.1016/s0092-8240(75)80039-5

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✦ Synopsis

A number of recent experiments have revealed the existence of mutants with different free run periods in their circadian rhythms. Parameter variations in mathematical models can be used to simulate such changes. I n addition, phase response curves (PRC) are derived and the effect of parameter variation in their shape is studied. I t is shown that changes in global parameters can also distort their shape. Therefore one cannot conclude that genetic experiments provide evidence in favor of "ehronon" models since "kinetic" models can also simulate their outcome.

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