Biological applications of the AFM: From single molecules to organs

✍ Scribed by S. Kasas; N. H. Thomson; B. L. Smith; P. K. Hansma; J. Miklossy; H. G. Hansma

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 270 KB
• Volume: 8
• Category: Article
• ISSN: 0899-9457
• DOI: 10.1002/(sici)1098-1098(1997)8:2<151::aid-ima2>3.0.co;2-9

✦ Synopsis

The application domains of the atomic force microscope between single molecules, measurement of the micromechanical have increased dramatically in recent years. We present a short review properties of the sample, and detection of protein motion. Finally, of the contributions of this microscope to biology. These are illustrated we will discuss the future of AFM in biology.

through the study of different samples, starting with the imaging of single molecules all the way up through the length scales, and ending with imaging of tissues. So that nonbiologists can appreciate the

II. WORKING PRINCIPLE

significance of these studies, special attention has been paid to a

The principle of the AFM is simple: a sharp tip fixed at the end description of the samples and to point out the motivation of these of a flexible cantilever is raster-scanned over the surface of a studies and their implications for the field of medicine. ᭧ 1997 John sample. As the tip interacts with the surface, the cantilever de-